Transient receptor potential (TRP) channels, which are important selective cation channels located inthe cell membrane, are widely expressed in the human respiratory tract, digestive tract, liver, and heart. Many studies havedemonstrated the involvement of TRP channels in the development and progression of malignant tumors. Herein, we reviewthe roles of TRP channels in the development, progression, and treatment of digestive tumors. We hope to provide furtherunderstanding of the mechanisms of pathogenesis and progression of digestive cancers, as well as an alternative direction for their treatment.