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首页 > 过刊浏览>2019年第29卷第7期 >24-28. DOI:10.3969/j. issn. 1671 -7856. 2019. 07. 004
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老年和青年C57BL/ 6J 小鼠外周血及免疫细胞分型测定分析
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(1.中国医学科学院医学实验动物研究所,北京协和医学院比较医学中心,国家卫生健康委员会人类疾病比较医学重点实验室,北京市人类重大疾病实验动物模型工程技术研究中心,北京 100021; 2.中国医学科学院/ 北京协和医学院放射医学研究所,天津市放射医学与分子核医学重点实验室,天津 300192)

中图分类号:

R-33


Difference in changes of peripheral blood and immune cell phenotypes between aged and young C57BL / 6J mice
Author:
  • GUAN Bowen 1

    GUAN Bowen

    Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences; Comparative Medicine Center,Peking Union Medical College; NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Engineering Research Center for Laboratory Animal Models of Human Critical Diseases, Beijing 100021,China.
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  • LU Yanhua 1

    LU Yanhua

    Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences; Comparative Medicine Center,Peking Union Medical College; NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Engineering Research Center for Laboratory Animal Models of Human Critical Diseases, Beijing 100021,China.
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  • SU Lulu 1

    SU Lulu

    Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences; Comparative Medicine Center,Peking Union Medical College; NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Engineering Research Center for Laboratory Animal Models of Human Critical Diseases, Beijing 100021,China.
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  • WANG Yuquan 1

    WANG Yuquan

    Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences; Comparative Medicine Center,Peking Union Medical College; NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Engineering Research Center for Laboratory Animal Models of Human Critical Diseases, Beijing 100021,China.
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  • LI Deguan 2

    LI Deguan

    Institute of Radiation Medicine,Chinese Academy of Medical Sciences and Peking Union Medical College;Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine,Tianjin 300192
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  • MENG Aimin 1

    MENG Aimin

    Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences; Comparative Medicine Center,Peking Union Medical College; NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Engineering Research Center for Laboratory Animal Models of Human Critical Diseases, Beijing 100021,China
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Affiliation:

(1. Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences; Comparative Medicine Center,Peking Union Medical College; NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Engineering Research Center for Laboratory Animal Models of Human Critical Diseases, Beijing 100021,China.2. Institute of Radiation Medicine,Chinese Academy of Medical Sciences and Peking Union Medical College;Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine,Tianjin 300192)

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    摘要:

    目的 比较观察老年C57BL/6J 小鼠与年轻C57BL/6J 小鼠外周血及免疫系统相关指标的差异?方法 19 月龄和2 月龄的C57BL/6J 小鼠分别取材检测外周血细胞计数?免疫脏器指数和外周血免疫细胞分型?结果 与年轻小鼠比较,老年小鼠外周血中红细胞和血小板计数升高,中性粒细胞比例升高,淋巴细胞比例下降( P <0. 001),CD4+细胞比例明显降低( P <0. 001),胸腺指数明显降低( P <0. 001)?结论 老年小鼠血细胞发生分化偏移,辅助性T 细胞数量下降,与年轻小鼠有明显差异,与人造血免疫老龄化改变类似?本项研究为免疫衰老相关问题研究提供基础数据?

    Abstract:

    Objective To investigate the changes of peripheral blood and immune cell phenotypes between agedand young C57BL/6J mice. Methods Peripheral blood cell count, immune organ coefficient and peripheral blood immunecell phenotype in aged C57BL/6J mice (19 months) and 2-month-old C57BL/6J mice used as control adult mice wereanalyzed. Results Compared with young mice, the aged mice had an increased peripheral blood platelet count, increasedproportion of neutrophils, and a decreased proportion of lymphocytes ( P <0. 001). The thymus coefficient was significantlyreduced ( P <0. 001). The percentage of CD4+ cells in the peripheral blood immune cell typing was obviously reduced ( P <0. 001). Conclusions The blood cells in aged mice are differentially skewed, and helper T-cell numbers declined. Thechanges are similar to those in the aging human. This study provides basic data for research on immuno-senescence.

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管博文,卢延华,苏路路,王玉全,李德冠,孟爱民.老年和青年C57BL/ 6J 小鼠外周血及免疫细胞分型测定分析[J].中国比较医学杂志,2019,29(7):24~28.

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历史
  • 收稿日期:2019-02-19
  • 在线发布日期: 2019-08-01
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