(1.江苏省免疫与代谢重点实验室,徐州医科大学病原生物学与免疫学教研室,江苏徐州 221004;2.徐州医科大学临床医学系,江苏徐州 221004; 3.基础医学国家级实验教学示范中心(徐州医科大学),江苏徐州 221004)
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CHEN Qingqing
1. Jiangsu Key Laboratory of Immunity and Metabolism; Department of Pathogenic Biology and Immunology,Xuzhou Medical University, Xuzhou 221004, China. 2. Department of Clinical Medicine, Xuzhou Medical University,Xuzhou 221004. 3. National Experimental Teaching Demonstration Center of Basic Medicine (Xuzhou Medical University), Xuzhou 221004ZHANG Xin
1. Jiangsu Key Laboratory of Immunity and Metabolism; Department of Pathogenic Biology and Immunology,Xuzhou Medical University, Xuzhou 221004, China. 2. Department of Clinical Medicine, Xuzhou Medical University,Xuzhou 221004. 3. National Experimental Teaching Demonstration Center of Basic Medicine (Xuzhou Medical University), Xuzhou 221004YANG Xiaoying
1. Jiangsu Key Laboratory of Immunity and Metabolism; Department of Pathogenic Biology and Immunology,Xuzhou Medical University, Xuzhou 221004, China.2. National Experimental Teaching Demonstration Center of Basic Medicine (Xuzhou Medical University), Xuzhou 221004(1. Jiangsu Key Laboratory of Immunity and Metabolism; Department of Pathogenic Biology and Immunology,Xuzhou Medical University, Xuzhou 221004, China. 2. Department of Clinical Medicine, Xuzhou Medical University,Xuzhou 221004. 3. National Experimental Teaching Demonstration Center of Basic Medicine (Xuzhou Medical University), Xuzhou 221004)
肝纤维化是指肝在修复各种致病因子所致肝损伤时出现的肝内弥漫性细胞外基质过度沉积?近年来,越来越多证据表明第10 号染色体缺失的磷酸酶张力蛋白同源物基因(phosphatase and tensin homology deleted on chromosome ten,PTEN)参与肝纤维化进程?本文就PTEN 调控肝纤维化的机制研究进行综述?
Liver fibrosis is caused due to excessive deposition of diffuse extracellular matrix in the liver duringrepair of liver injury caused by various pathogenic factors. In recent years, an increasing body of evidence has suggestedthat the phosphatase and tensin homology deleted on chromosome 10 (PTEN) is involved in the development of liver fibrosis. We therefore reviewed the regulatory mechanism of PTEN in liver fibrosis.
陈晴晴,孙芬芬,张欣,潘伟,杨晓莹. PTEN 在肝纤维化中的研究进展[J].中国比较医学杂志,2019,29(7):92~95.
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