抗氧化剂拮抗子宫内膜异位症的研究进展
作者:
作者单位:

(1. 上海市计划生育科学研究所药理毒理学研究室,中国生育调节药物毒理检测中心;2. 复旦大学生殖与发育研究院;3. 国家人口和计划生育委员会计划生育药具重点实验室,上海 200032)

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R-33


Progress in research on the effects of antioxidants on endometriosis
Author:
  • WANG Liping

    WANG Liping

    1. Department of Pharmcology and Toxicology, Shanghai Institute of Planned Parenthood Research,National Evaluation Center for Toxicology of Fertility Regulating Drugs; 2. Reproductive and Developmental Research Institute of Fudan University; 3. Key Laboratory of Reproduction Regulation of NPFPC,Shanghai 200032, China
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  • SUN Zuyue

    SUN Zuyue

    1. Department of Pharmcology and Toxicology, Shanghai Institute of Planned Parenthood Research,National Evaluation Center for Toxicology of Fertility Regulating Drugs; 2. Reproductive and Developmental Research Institute of Fudan University; 3. Key Laboratory of Reproduction Regulation of NPFPC,Shanghai 200032, China
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Affiliation:

(1. Department of Pharmcology and Toxicology, Shanghai Institute of Planned Parenthood Research,National Evaluation Center for Toxicology of Fertility Regulating Drugs; 2. Reproductive and Developmental Research Institute of Fudan University; 3. Key Laboratory of Reproduction Regulation of NPFPC,Shanghai 200032, China)

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    摘要:

    子宫内膜异位症(endometriosis,EMT)是临床上较常见的一种良性?慢性妇科疾病?抗氧化剂因其抗氧化?抗炎?抗衰老等功效广泛用作治疗药品和保健品?据报道,抗氧化剂可从抗氧化物质和氧化物质水平?异位内膜组织体积?炎症因子水平?新血管形成和细胞凋亡等方面拮抗EMT,这可为EMT 的治疗提供新思路,但其确切的作用效果及其作用机制仍有待进一步的深入研究?

    Abstract:

    Endometriosis is a benign, chronic, and common gynecologic disease in the clinical setting. Antioxidants have been applied as drugs and health care products because of their antioxidant, anti-inflammatory, and antiaging properties. The antagonistic effects of antioxidants on endometriosis can reportedly be assessed by measurement of the total antioxidant status and total oxidant status, volumes of endometriotic tissues, levels of inflammatory cytokines, neovascularization, apoptosis, and other parameters, which might lead to the establishment of a novel treatment for endometriosis. However, further studies are needed to determine the exact effects and mechanisms.

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王莉萍,孙祖越.抗氧化剂拮抗子宫内膜异位症的研究进展[J].中国比较医学杂志,2019,29(10):131~135.

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  • 收稿日期:2019-04-08
  • 在线发布日期: 2019-11-07
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