比格犬阴茎背神经切除术中神经电生理检测模型的建立及意义
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(1.南京医科大学研究生院,南京 211166; 2.南京医科大学附属江宁医院,南京 211100;3.南京医科大学鼓楼临床医学院,南京 210008)

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R-33


Establishment and significance of a beagle dog model of electrophysiological detection during resection of the penile dorsal nerve
Author:
Affiliation:

(1. Graduate School of Nanjing Medical University, Nanjing 211166,China. 2. Jiangning Hospital Affiliated to Nanjing Medical University, Nanjing 211100. 3. Drum Tower Clinical Medical College of Nanjing Medical University,Nanjing 210008)

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    摘要:

    目的 探讨全麻下比格犬阴茎体感诱发电位的检测方法及阴茎背神经切除过程中体感诱发电位的变化,为进一步研究提供参考。方法 对5 只比格犬进行全麻下阴茎背神经切除术中阴茎头及阴茎背神经体感诱发电位检测,观察波形及参数值。结果 全麻下可获得较稳定的比格犬GPSEP、DNSEP 波形,5 只比格犬全麻下GPSEP 平均潜伏期为(41. 84±1. 41) ms,平均波幅(1. 56±0. 26) μV;DNSEP 平均潜伏期为(33. 46±2. 45) ms,波幅平均(1. 80±0. 52) μV。比格犬阴茎背神经切除过程中,DNSEP 及GPSEP 潜伏期存在变化,且差异具有显著性( P <0. 05)。结论 全麻下阴茎体感诱发电位检测是可行性的,波形较稳定;在进行阴茎背神经切除过程中DNSEP 及GPSEP 潜伏期可能存在变化,有望为进一步研究提供实验动物依据。

    Abstract:

    Objective To explore the method of detecting penile somatosensory evoked potential (SEP) in beagle dogs under general anesthesia and the changes of SEP during the process of dorsal penile nerve resection as reference material for further study. Methods Glans penis (GP) and dorsal penile nerve (DN) SEP were measured under general anesthesia and during resection of the dorsal penile nerve in five beagle dogs. The waveforms and parameters were observed. Results Stable waveforms of penile SEP were obtained under general anesthesia in beagle dogs. The average latency of GPSEP was 41. 84±1. 41 ms with an average amplitude of 1. 56±0. 26 μV, while the average latency of DNSEP was 33. 46 ±2. 45 ms with an average amplitude of 1. 80±0. 52 μV. The latency of penile SEP changed significantly during the process of resection of the dorsal penile nerve in the dogs ( P < 0. 05). Conclusions Detection of penile SEP under general anesthesia is feasible and its waveform is stable. There are changes in the latency of penile SEP during the process of resection of the dorsal penile nerve, which can provide an experimental animal basis for further study of the treatment of erectile dysfunction and premature ejaculation.

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唐庆来,宋涛,韩友峰,仇玮,徐春璐,钱丽萍,吴鸿雁,史烔,戴玉田.比格犬阴茎背神经切除术中神经电生理检测模型的建立及意义[J].中国比较医学杂志,2019,29(12):98~103.

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  • 收稿日期:2019-05-16
  • 在线发布日期: 2020-01-13
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