Wild-type p53 induced phosphatase 1 ( Wip1) is encoded by Ppm1d, a member of the protein phosphatase type 2C ( PP2C) phosphatase family and has an important role in several stress signaling pathways. Many previous studies have shown that Wip1 has a role in regulating transcription factors as well as being a p53 target. For example, Wip1 is crucial for cellular homeostasis by creating a negative feedback loop with p53, p38 / MAPK, and other factors. Thus, Wip1 plays a vital role in the regulation of the cell cycle and inhibiting apoptosis, DNA repair, and inflammation. In this review, we will discuss the function Wip1 related to these functions.