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首页 > 过刊浏览>2020年第30卷第4期 >121-130. DOI:10. 3969 / j.issn.1671-7856. 2020. 04. 019
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降脂模型研究进展
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成都中医药大学 药学院,教育部中药材标准化重点实验室,中药资源系统研究与开发利用省部共建国家重点 实验室培育基地,成都 611137

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R-33


Progress in lipid-lowering model research
Author:
  • WANG Cheng

    WANG Cheng

    Pharmacy College, Chengdu University of Traditional Chinese Medicine, Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources Co-Founded by Sichuan Province and Ministry of Science and Technology, Chengdu 611137, China
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  • HU Naihua

    HU Naihua

    Pharmacy College, Chengdu University of Traditional Chinese Medicine, Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources Co-Founded by Sichuan Province and Ministry of Science and Technology, Chengdu 611137, China
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  • YU Linyuan

    YU Linyuan

    Pharmacy College, Chengdu University of Traditional Chinese Medicine, Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources Co-Founded by Sichuan Province and Ministry of Science and Technology, Chengdu 611137, China
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  • GONG Lihong

    GONG Lihong

    Pharmacy College, Chengdu University of Traditional Chinese Medicine, Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources Co-Founded by Sichuan Province and Ministry of Science and Technology, Chengdu 611137, China
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  • DAI Xuyang

    DAI Xuyang

    Pharmacy College, Chengdu University of Traditional Chinese Medicine, Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources Co-Founded by Sichuan Province and Ministry of Science and Technology, Chengdu 611137, China
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  • LI Yunxia

    LI Yunxia

    Pharmacy College, Chengdu University of Traditional Chinese Medicine, Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources Co-Founded by Sichuan Province and Ministry of Science and Technology, Chengdu 611137, China
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Affiliation:

Pharmacy College, Chengdu University of Traditional Chinese Medicine, Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources Co-Founded by Sichuan Province and Ministry of Science and Technology, Chengdu 611137, China

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    摘要:

    高脂血症是一种脂质代谢紊乱性疾病,也是导致冠心病、脑梗死、动脉粥样硬化等心脑血管疾病的首要因素,已成为危害全人类身体健康的“第一杀手”。目前,研发高效低毒的新靶点降脂中药对改善高脂血症及其继发的心脑血管性疾病至关重要。但是,由于我国中药成分的复杂性和配伍的多样性,依靠单一的降脂模型很 难对发挥疗效的有效成分和具体的降脂机制进行深层次的研究。因此,建立一个理想的高脂模型是筛选降脂中药 和研究高脂血症中医发病机理的关键因素之一。本文从细胞模型、哺乳动物模型和斑马鱼模型三个方面对目前几 种最常用的降脂模型进行了综述,总结归纳了各种模型的常用造模方法及各自的优缺点,以期为复制高脂血症的 模型选择、高脂血症的机制研究以及筛选高效降脂中药提供参考和实验依据。

    Abstract:

    Hyperlipidemia is a type of disease involving lipid metabolism disorders. It is also the leading cause of cardiovascular and cerebrovascular diseases, such as coronary heart disease, cerebral infarction and atherosclerosis, which have become one of the most harmful chronic diseases to human health in the word. At present, the development of new, high-efficiency and low-toxicity target, lipid-lowering, hypolipidemic, traditional Chinese medicines is essential for improving hyperlipidemia and its secondary cardiovascular and cerebrovascular diseases. However, because of the complexity and compatibility of traditional Chinese medicine ingredients, it is difficult to conduct in-depth research on the effective components of the therapeutic effect and the specific lipid-lowering mechanism by relying on a single lipid-lowering model. Therefore, the establishment of an ideal high-fat model is a key factor in screening lipid-lowering Chinese medicines and studying the pathogenesis of hyperlipidemia. In this paper, several of the most commonly used lipid-lowering models were reviewed from three aspects: cell models, mammalian models and zebrafish models, and the common modeling method of various models and their respective advantages and disadvantages were summarized. As a result , this work provides references and an experimental basis for selecting reproducible hyperlipidemia models for hyperlipidemia mechanism research and screening of effective lipid-lowering traditional Chinese medicines.

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王 成,胡乃华,余琳媛,龚莉虹,代旭阳,李芸霞.降脂模型研究进展[J].中国比较医学杂志,2020,30(4):121~130.

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历史
  • 收稿日期:2019-07-24
  • 在线发布日期: 2020-05-14
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