Efforts to improve the welfare ethics review of laboratory animals have been increasingly valued in the development of human ethics and morality and the accuracy of experimental data. Currently, laboratory animals, as basic and important scientific research resources, play a major role in the development of life sciences, medical research, and pharmaceutical research. To protect the welfare of laboratory animals, regulate the ethical review of laboratory animals, and monitor the professional behavior of laboratory animal practitioners, the regulation of welfare and ethics of laboratory animals and the Institutional Animal Care and Use Committee ( IACUC) have been established in Chinese scientific research institutions. These can effectively ensure laboratory animal welfare and animal experimental ethics. Sadly, not all institutions have these committees and not all guidelines and regulations are enforced. There appear to be some problems, such as awareness, processes, and operations. These will be described in this paper, which will help to analyze the reasons for these issues, propose countermeasures, and provide suggestions to overcome these limitations.