Objective To investigate the effect of Yupingfeng powder on the expression of retinoic acid-related orphan nuclear receptor γt (RORγt) and related factors in experimental allergic rhinitis (AR) rats. Methods Forty SD rats were randomly divided into a normal group, model group, Yupingfeng group, and cetirizine group, with 10 rats in each group. The AR rat model of allergic rhinitis was established using the egg albumin sensitization method . The Yupingfeng powder doses were calculated according to the rats’ weights as the Yupingfeng group, 10 g / kg and cetirizine group, 2 mg / kg. The normal group and the model group were given the same amount of physiological salt by gavage, and the secretion levels of cytokines IL-17, TNF-α, IL-23, and IL-6 in the rats’ nasal mucosa in each group were detected by ELISA. H&E staining was used to detect the degree of damage to the nasal mucosal tissues in each group. The expression of ROR Tprotein in rat nasal mucosa was detected by immunohistochemistry. The mRNA expressions of RORγt, IL-17, and IL-23 in the nasal mucosa of the rats in each group were detected by RT-PCR. Results Compared with the normal group, nasal symptom scores, nasal mucosal thickness, expression levels of cytokines IL-17, TNF-α, IL-23, and IL-6, and the mRNA levels of RORγt, IL-17, and IL-23 were significantly increased in the model group (P<0. 05). Compared with the model group, values for the above indices in the Yupingfeng group and cetirizine group were significantly lower ( P < 0. 05). Conclusions Yupingfeng powder can regulate the expression of ROR T and the related factors, IL-17 and IL-23, and play an immunomodulatory role in AR.