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PM2. 5 通过增加海马神经炎症引起小鼠的认知障碍
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中国医学科学院医学实验动物研究所,北京协和医学院比较医学中心,国家卫生健康委员会人类疾病比较医学 重点实验室,北京市人类重大疾病实验动物模型工程技术研究中心,北京 100021

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R-33


Particulate matter 2.5 aggravates cognitive impairment in mice via hippocampal neuroinflammation
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  • FU Xinjing

    FU Xinjing

    Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS), Comparative Medicine Center, Peking Union Medical College (PUMC), NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Beijing 100021, China
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  • ZHANG Yu

    ZHANG Yu

    Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS), Comparative Medicine Center, Peking Union Medical College (PUMC), NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Beijing 100021, China
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  • GUO Jianguo

    GUO Jianguo

    Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS), Comparative Medicine Center, Peking Union Medical College (PUMC), NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Beijing 100021, China
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  • ZHANG Ling

    ZHANG Ling

    Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS), Comparative Medicine Center, Peking Union Medical College (PUMC), NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Beijing 100021, China
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  • QIN Chuan

    QIN Chuan

    Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS), Comparative Medicine Center, Peking Union Medical College (PUMC), NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Beijing 100021, China
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Affiliation:

Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS), Comparative Medicine Center, Peking Union Medical College (PUMC), NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Beijing 100021, China

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    摘要:

    目的 空气细颗粒物 PM2. 5 是空气污染物的重要组成部分,能通过多种途径引起呼吸系统及各个器官系统疾病。 值得注意的是,PM2. 5 可引起认知减退,其具体机制尚不明确。 本研究旨在探索空气污染物 PM2. 5 的环境暴露影响动物认知功能的机制。 方法 本研究采用狭缝分离式 PM2. 5 在线浓缩富集系统进行小鼠的 PM2. 5 富集与暴露造模,选用 C57BL/ 6 小鼠,进行每天 4 h、每周 5 d、共 15 周的 PM2. 5 暴露,建立小鼠的 PM2. 5 呼吸暴露模型。 造模成功后,分别检测动物的行为学症状、病理学变化、以及相关分子机制。 结果 实验结果表明,PM2. 5 暴露可造成小鼠肺组织的病理改变,引起小鼠的认知障碍症状,免疫组织化学染色检测到小鼠中枢神经系统海马脑区出现小胶质细胞的激活,小鼠中枢神经系统 IL-6 含量增加。 另外,PM2. 5 暴露未造成小鼠其他主要脏器损伤。 结论 本研究表明,空气细颗粒物 PM2. 5 可导致中枢神经系统炎症,促进小胶质细胞激活,从而引起 C57BL/ 6 小鼠的认知障碍。

    Abstract:

    Objective Particulate matter 2. 5 (PM2. 5) is an important source of air pollution and can cause respiratory and other systemic diseases. Additionally, PM2. 5 can cause cognitive decline, though the exact mechanism is not clear. This study aimed to explore the mechanism by which exposure to environmental PM2. 5 via air pollution induces cognitive impairment. Methods This study used the PM2. 5 online collection and exposure system on C57BL/ 6 mice to make a PM2. 5 exposure mouse model. Mice were exposed for 4 h per day, 5 days per week, for 15 weeks. After the model was established, mouse behavioral symptoms, pathological features and related molecular mechanisms were examined in each group. Results PM2. 5 exposure result ed in pathological changes in lung tissue in mice and exacerbated their cognitive impairment. Immunohistochemical staining of the central nervous system detected microglial cell activation. The level of IL-6 also increased in the central nervous system of exposed mice compared with control mice. PM2. 5 exposure did not cause damage to other major organs in the mice. Conclusions The result suggest that PM2. 5 induced neuroinflammation and promoted the activation of microglial cells in the hippocampus, thus aggravating cognitive impairment in mice.

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付信靖,张 钰,郭建国,张 玲,秦 川. PM2. 5 通过增加海马神经炎症引起小鼠的认知障碍[J].中国比较医学杂志,2021,31(4):9~14.

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  • 收稿日期:2020-12-01
  • 在线发布日期: 2021-05-28
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