Objective To observe the effect of Fushen recipe on peritoneal function and on peritoneal levels of VEGF, TNF-α, IL-12, and IFN-γ in uremic peritoneal dialysis rats. Methods Fifty male Sprague Dawley rats were divided into 5 groups according to random number table method: normal control, model ( uremic peritoneal dialysis), model + low-dose Fushen recipe intervention, model + high-dose Fushen recipe intervention, and model + celecoxib intervention. A model of uremia was established by 5 / 6 nephrectomy and a peritoneal dialysis model was established by intraperitoneal injection of peritoneal dialysis solution. Peritoneal tissues of rats in each group were collected after continuous administration for 4 weeks. Hematoxylin and eosin staining was used to observe morphological changes of peritoneal tissues, a peritoneal balance test was used to detect peritoneal transport function, and a liquid chip method was used to detect the levels of VEGF, TNF-α, IL-12 and IFN-γ in peritoneal tissues. Results Compared to normal controls, the expression of VEGF and TNF-α in peritoneal tissue of model group rats was up-regulated, and the expression of IL-12 and IFN-γ was down-regulated (P<0.05, P<0.01, respectively). Compared to normal controls, the expression of VEGF and TNF-α was down-regulated and the expression of IL-12 and IFN-γ was up-regulated in the low-dose Fushen recipe group (P< 0.05, P< 0.01, respectively). The expression of VEGF, IL-12, and IFN-γ in the high-dose group and the celecoxib group was down-regulated (P<0.01). Conclusions Fushen recipe can alleviate peritoneal injury and improve peritoneal ultrafiltration function in uremic peritoneal dialysis rats, which may be related to down-regulation of VEGF and TNF-α, and up-regulation of IL-12 and IFN-γ, which are angiogenesis promoting factors in peritoneal tissue.