Angiogenesis is closely related to many diseases and plays an important role in the development and prognosis of diseases. Long non-coding RNAs ( lncRNAs) are important regulatory molecules of angiogenesis that are involved in the pathological recovery process of ischemic stroke, tumor, atherosclerosis and other diseases by regulating the phenotypic transformation of vascular endothelial cells, angiogenic factors and miRNA expression. Here, we review the biological functions of lncRNAs, and describe their expression and regulatory effects in angiogenesis and vascular diseases to provide reference for ongoing research into lncRNA mechanisms of action and their clinical application in angiogenesis.