Research progress of establishing atherosclerosis model in rabbits
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Department of Cardiovascular Medicine, Shandong First Medical University Central Hospital, Jinan 250013, China
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摘要:
兔与灵长类动物具有相似的进化历史,具有与人类相似的血管形态特征。 另外,兔是对胆固醇超载十分敏感的动物物种,进食含高胆固醇饲料后,短时间内可形成高胆固醇血症,所以在快速、简洁地建立动脉粥样硬化(AS)模型方面,兔具有着独特的优势。至今已有多种建立兔 AS 动物模型的方法,除传统的高脂饲料喂养方 法外,还包括股动脉球囊拉伤联合高脂饲料喂养以及 CRISPR/ Cas9 基因编辑技术等新兴建模方法的出现。 本文对近些年常用及新兴兔 AS 模型的建立方法及其优缺点进行综述。
Abstract:
Rabbits and primates have similar evolutionary history and vascular morphological characteristics similar to humans. In addition, rabbits are very sensitive to cholesterol overload. After eating a high cholesterol diet, hypercholesterolemia can be formed in a short time. Therefore, rabbits have unique advantages to establish atherosclerosis models rapidly and concisely. Many method establish rabbit as animal models, including the traditional high-fat diet feeding method , the femoral artery balloon injury combined with high-fat diet feeding, CRISPR/ Cas9 gene editing technology and other emerging modeling method . In this paper, we review the establishment method and advantages and disadvantages of rabbit as models commonly used and emerging in recent years.