Testicular orphan nuclear receptor 4 (TR4)plays an important regulatory role in many key physiological processes, and the signal dysregulation it controls are related to many diseases. In recent years, the role of TR4 in prostate cancer has received increasing attention. Systematic analysis and understanding of the role of TR4 in the initiation, development, and treatment of prostate cancer are of great significance to improving the precise treatment strategy for prostate cancer.