AbstractArrhythmia is one of the most common abnormalities of the circulatory system and can affect the functions of many important organs, including the heart, brain, and kidneys. Severe arrhythmia can be life-threatening; sudden cardiac death caused by arrhythmia accounts for approximately 25% of all deaths. The underlying pathophysiological mechanism of arrhythmia remains incompletely understood. In-depth research on the pathogenesis of arrhythmia is helpful to the development of new clinical prevention and treatment strategies, and the establishment of precision animal models is an important basis for the study of pathogenesis. Such models are not only effective research tools but can also be used for the study of pathogenesis and drug intervention measures. Therefore, this article summarizes and compares the progress in research using animal models of arrhythmia in China and abroad, including the species characteristics of the model application, the preparation principle, and the model application. The overall aim is to provide a basis for the selection of models for arrhythmia-related research.