星形胶质细胞对阿尔兹海默病的双向作用
作者:
作者单位:

1.河南中医药大学中医药科学院,郑州 450046; 2.河南中医药大学基础医学院,郑州 450046

中图分类号:

R-33


Bidirectional effect of astrocytes on Alzheimer’s disease
Author:
Affiliation:

1.College of Traditional Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China. 2. School of Basic Medical Science, Henan University of Chinese Medicine, Zhengzhou 450046

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    摘要:

    阿尔兹海默病(Alzheimer’s disease,AD)是一种由多因素导致的神经退行性疾病,其致病因素十分复杂。 病理特征为 β-淀粉样蛋白在脑中沉淀,Tau 蛋白过度磷酸化导致神经元纤维缠结和大脑萎缩。 临床上以大脑认知功能障碍和记忆力减退为主要表现症状。 星形胶质细胞在中枢神经系统中分布广,数量多。通过多种机制 在 AD 发生发展的不同时期中产生保护或有害作用。 近年来,星形胶质细胞在 AD 的病理生理机制中受到的关注越来越密切。 本文将以目前星形胶质细胞研究领域的现状为核心,重点阐述其功能特征以及与 AD 病理特征相关性的最新研究进展,以期为 AD 等神经退行性疾病的治疗提供理论基础。

    Abstract:

    Alzheimer’ s disease ( AD) is a widespread neurodegenerative disease caused by complicated pathogenic factors. Its pathological features include β-amyloid precipitation in the brain, neurofibrillary tangles, and brain atrophy, and its clinical manifestations are brain cognitive dysfunction and memory loss. Astrocytes are widely distributed and abundant in the central nervous system. These cells can have protective or harmful effects in different periods of the disease course of AD through a variety of mechanisms. In recent years, astrocytes have received increasingly more attention with respect to their role in the pathophysiological mechanism of AD. This article focuses on the current status of the field of astrocyte research, especially their functional characteristics and the latest research progress in the pathological characteristics of AD. The overall aim of this report is to provide a theoretical basis for the treatment of AD and other neurodegenerative diseases.

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原 野,余姊阳,邵思迈,史 洺,张紫娟,郝 莉,张振强.星形胶质细胞对阿尔兹海默病的双向作用[J].中国比较医学杂志,2021,31(6):133~138.

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  • 收稿日期:2020-08-17
  • 在线发布日期: 2021-08-03
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