Allergic diseases are prevalent and they continue to affect human health. It is urgent to explore their pathogenesis and effective treatment method . In this process of exploration, the establishment of allergic disease models is a key factor. According to the classification of allergic diseases in different systems of the body, this article summarizes and analyzes the existing in vivo and in vitro models of allergic diseases, and compares the similarities, differences, advantages and disadvantages among them, aiming to provide information for the development and application of allergic disease models.