蛋白的酪氨酸磷酸化信号通路与阿尔茨海默病的关系
作者:
作者单位:

1.重庆医科大学附属永川医院, 重庆 永川 402160; 2.西南医科大学基础医学院组织胚胎学教研室, 四川 泸州 646000

中图分类号:

R-33


The relationship between the tyrosine phosphorylation signaling pathways and Alzheimer’s disease
Author:
Affiliation:

1.Yongchuan Hospital of Chongqing Medical University, Yongchuan 402160, China. 2. Department of Histology and Embryology, School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000

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    摘要:

    蛋白酪氨酸磷酸化信号通路是广泛存在于细胞中的重要信号转导通路,其功能与细胞增值、分化、转化及凋亡密切相关。阿尔茨海默病是一种神经系统退行性疾病,与年龄相关,具有隐匿发病、进行发展的特点。 其主要病理特征为 β-淀粉样蛋白( amyloid protein β, Aβ) 聚集, Tau 蛋白异常磷酸化后形成神经纤维缠结 (neurofibrillary tangle, NFT)。 酪氨酸激酶抑制剂治疗阿尔茨海默病已成为现代医学研究的一大热门,故对蛋白酪氨酸磷酸化信号通路与阿尔茨海默病关系的基础研究进展作以下简要综述。

    Abstract:

    The protein tyrosine phosphorylation signal pathways are important signal transduction pathways, which are widely present in cells. Their function is closely related to cell proliferation, differentiation, transformation and apoptosis. Alzheimer’s disease (AD) is a degenerative disease of the nervous system. Age is the greatest risk factor for AD, and the likelihood of suffering from AD is age dependent. The main pathological features are the aggregation of β- amyloid protein and abnormal phosphorylation of Tau protein. The treatment of AD with tyrosine kinase inhibitors has become a greatly discussed topic in modern medical research. Therefore, the basic research progress of the relationship between the protein tyrosine phosphorylation signaling pathways and AD is briefly reviewed in this paper.

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李雅娟,孙姣姣,刘广益,于 洋.蛋白的酪氨酸磷酸化信号通路与阿尔茨海默病的关系[J].中国比较医学杂志,2021,31(7):147~152.

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  • 收稿日期:2020-08-14
  • 在线发布日期: 2021-08-27
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