Stress-induced gastric ulcers( SGU) is a disease in which the body suffers from stress,Resultsing in cell metabolism disorders and damage, and eventually causing acute erosion and ulcers of the gastric mucosa. The pathogenesis of SGU is still unclear. Understanding the signaling pathways related to SGU is of great significance for further research into the pathogenesis of SGU and the search for potential therapeutic targets. This article reviews the research progress of SGU-related signal pathways, and shows that SGU and the JAK/ STAT, Nrf2 / HO-1, NF-κB, ERK1 / 2, Hedgehog, TLR, and PI3K/ Akt signaling pathways are closely related. The goal of this review is to provide a certain scientific basis for the study of the pathogenesis of SGU and potential new treatment method .