阿尔茨海默病中的 β 淀粉样肽与氧化应激
作者:
作者单位:

1.河南中医药大学基础医学院,郑州 450046;2.河南中医药大学中医药科学院,郑州 450046

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R-33


Amyloid-β protein and oxidative stress in Alzheimer’s disease
Author:
Affiliation:

1.School of Basic Medical Science, Henan University of Chinese Medicine, Zhengzhou 450046, China. 2. College of Traditional Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou 450046

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    摘要:

    氧化应激(oxidative stress)是影响衰老和神经系统疾病的重要因素,在多种神经退行性疾病发生发展过程中起重要作用。老年斑的主要成分是 β 淀粉样蛋白(amyloid-beta protein,Aβ),它在脑中的异常沉积是阿尔茨海默病(Alzheimer’s disease,AD)发病的关键因素。 研究表明,Aβ 沉积引发的氧化应激会诱导认知记忆相关脑区的神经元丢失、死亡,最终引起 AD 病理的发生与发展。 本文重点论述 AD 发生发展中淀粉样肽毒性产生的机制,大分子的氧化过程及淀粉样肽与氧化应激相互影响的过程,旨在阐明 AD 发生发展过程中淀粉样肽与氧化应激的关系,为促进 AD 抗氧化剂研究提供有力的理论支持和研究思路。

    Abstract:

    Oxidative stress is an major factor that affects aging and neurological diseases, which plays an crucial role in the development and progression of multiple neurodegenerative diseases. Amyloid-beta protein ( Aβ) is a major component of senile plaques, and its aggregation and abnormal deposition are major contributors to the pathogenesis of Alzheimer’s disease (AD). Studies have shown that oxidative stress triggered by Aβ deposition induces neuronal loss, cell death in cognitive memory-related brain regions, and finally causes the occurrence and development of AD pathology. This article focuses on the mechanism of toxic production of amyloid peptide in the occurrence and development of AD, the oxidation process of macromolecules and the process of the interaction between amyloid peptide and oxidative stress to clarify the relationship between amyloid peptide and oxidative stress in the occurrence and development of AD. This review provides strong theoretical support and research directions to promote studies on antioxidants in AD.

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邵思迈,史 洺,余姊阳,原 野,游言文,郝 莉,张紫娟,张振强.阿尔茨海默病中的 β 淀粉样肽与氧化应激[J].中国比较医学杂志,2021,31(10):131~135.

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  • 收稿日期:2020-12-07
  • 在线发布日期: 2021-11-29
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