基于化学诱导炎症性肠病动物模型的中药研究进展
作者:
作者单位:

1.湖南中医药大学湘产大宗药材品质评价湖南省重点实验室,长沙 410208;2.湖南农业大学,长沙 410128

中图分类号:

R-33


Research progress of traditional Chinese medicine on the basis of animal models of chemically-induced inflammatory bowel disease
Author:
Affiliation:

1.Hunan Key Laboratory for Quality Evaluation of Bulk Medicinal Materials Produced in Hunan, Hunan University of Traditional Chinese Medicine, Changsha 410208, China. 2. Hunan Key Laboratory of Traditional Chinese Veterinary Medicine, Hunan Agricultural University, Changsha 410128

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    摘要:

    炎症性肠病(IBD)是遗传、环境及免疫等多种因素共同作用的结果。 该疾病虽归为西医难治性疾病,但中医辨证治疗 IBD 优势显著。 因此,针对探索中医药治疗 IBD 作用及机制研究中如何选择动物模型十分重要。化学诱导的小鼠 IBD 模型是研究 IBD 发病机制的最常用模型,本文就近年来中医药对该类模型的研究进展进行了整理,从模型特征、致病机制、研究思路和用途等方面进行了论述,以期为 IBD 基础研究设计提供帮助。

    Abstract:

    Inflammatory bowel disease (IBD) is the result of a combination of genetic, environmental and immune factors. Although the disease is classified as a refractory disease in modern medicine, it has significant advantages in treating IBD on the basis of traditional Chinese medicine syndrome differentiation. Therefore, it is very important to explore appropriate animal models to study the effects and mechanisms of traditional Chinese medicine in the treatment of IBD. The chemically induced IBD model is the most commonly used to study the pathogenesis of IBD. This article summarizes the recent research progress of this type of model in Chinese medicine and discusses the characteristics of the model, pathological mechanism, research ideas and applications to facilitate the design of basic research of IBD.

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引用本文

曹喻灵,宋厚盼,曾建国,廖端芳.基于化学诱导炎症性肠病动物模型的中药研究进展[J].中国比较医学杂志,2022,32(1):127~131.

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  • 收稿日期:2021-11-10
  • 在线发布日期: 2022-03-15
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