Programmed cell death (PCD) is a form of cell death regulated by genes. It plays an important role in the occurrence and development of tumors and other diseases. According to its occurrence, mechanism of action, and morphological characteristics, it can be divided into apoptosis, necroptosis, ferroptosis, pyroptosis and autophagy, among others. Long noncoding RNAs are noncoding RNAs of more than 200 nucleotides in length, which participate in the regulation of PCD by directly or indirectly affecting the expression of intracellular proteins and other molecules. This paper summarizes relevant literature on lncRNAs’ involvement in the regulation of PCD, which is expected to provide different pathways for further research on lncRNAs and PCD, as well as new ideas for diagnosis, treatment, and prevention of related clinical diseases.