Ischemic stroke, which has caused serious disease burden due to its high incidence rate, disability rate and mortality rate, is one of the key diseases that medical research and development personnel are concerned about. However, the conversion rate of preclinical research result of stroke to clinic is low, which highlights the urgent need for animal model optimization. Nonhuman primates ( NHPs) have higher similarities with humans in brain anatomy and physiology. Therefore, building models with NHPs is expected to promote the transformation from preclinical research to clinical treatment of ischemic stroke. This paper reviews the modeling method , evaluation indexes and model application progress of stroke NHPs model, discusses the advantages and disadvantages of recent models and evaluation method , and looks forward to the difficulties and possible development direction of NHPs model research in the future.