糖尿病心肌病体内与体外模型研究进展
作者:
作者单位:

1. 湖北大学生命科学学院生物催化与酶工程国家重点实验室,武汉 430062; 2. 华中科技大学生命科学与技术学院,武汉 430062

中图分类号:

R-33


Research progress of diabetic cardiomyopathy in in vivo and in vitro models
Author:
Affiliation:

1.State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Science, Hubei University, Wuhan 430062, China. 2. College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430062

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    摘要:

    糖尿病心肌病(diabetic cardiomyopathy, DCM)是由持续高血糖状态引起心脏结构和功能损伤的心肌病变,是糖尿病最常见的并发症,其表型独立于高血压和冠心病等心脏疾病而显著增加糖尿病患者心力衰竭的发生风险。糖尿病心肌病实验模型的开发将有助于深入研究其分子机理,进而开发糖尿病心肌病的诊疗新方案。本文总结了目前领域内常用的糖尿病心肌病动物模型和体外细胞研究模型,介绍了诱导性多能干细胞来源的人源心肌细胞糖尿病心肌病模型的优势,以期为糖尿病心肌病研究中模型的选取提供新的思路。

    Abstract:

    Diabetic cardiomyopathy (DCM) is a cardiomyopathy that presents as cardiac structural and functional damage caused by sustained high blood glucose. DCM is one of the most common diabetic complications. It significantly increases the risk of heart failure in diabetic individuals independent of other cardiovascular diseases such as hypertension and coronary heart disease. The development of DCM experimental models will be helpful for investigating the in-depth molecular mechanisms of DCM as well as for developing new diagnostic and therapeutic approaches for DCM. In this review, we summarize the common animal models and in vitro models of DCM. The advantages of human induced pluripotent stem cell-derived cardiomyocytes in establishing DCM models are introduced to provide an important new insight for studying DCM.

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刘 倩,姚雨峰,蔡 琳,张冬卉.糖尿病心肌病体内与体外模型研究进展[J].中国比较医学杂志,2022,32(8):131~136.

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  • 收稿日期:2021-10-04
  • 在线发布日期: 2022-12-29