Alzheimer’ s disease (AD) is a common degenerative disease of the central nervous system with unknown etiology and pathogenesis that has a large negative effect on the lives of patients and their families. The successful establishment of an animal model of AD in line with the occurrence and progression of human disease is particularly important for the exploration of the pathogenesis of the disease and the development of therapeutic drugs or other interventions. Therefore, to provide a reference for researchers in related fields to select appropriate animal models and to contribute ideas for the construction of new animal models and the development of new model index evaluation method , we reviewed the technical method , functional principles, and current applications of animal models of AD globally, summarized the evaluation method of relevant indicators, analyzed the advantages and disadvantages of transgenic and non- transgenic models of AD, and generalized the application prospects and characteristics of cognitive behavioral method, immunological method and imaging method.