1.内蒙古科技大学包头医学院,内蒙古 包头 014010;2.内蒙古科技大学包头医学院第一附属医院风湿免疫科,内蒙古 包头 014010;3.内蒙古科技大学包头医学院第一附属医院中心实验室(内蒙古自治区自体免疫学重点实验室),内蒙古 包头 014010
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WANG Yongfu
2.Department of Rheumatology, the First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014010. 3. Central Laboratory of the First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology (Key Laboratory of Autoimmunity of Inner Mongolia), Baotou 0140101. Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014010, China.2. Department of Rheumatology, the First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014010. 3. Central Laboratory of the First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology (Key Laboratory of Autoimmunity of Inner Mongolia), Baotou 014010
外泌体是可由大多数细胞分泌的小囊泡。外泌体及其包含的 microRNA、mRNA、蛋白质在细胞间通讯中起重要作用。研究表明外泌体具有免疫调节作用,参与自身免疫性疾病的发病及免疫治疗,并可作为诊断疾病的有效生物标志物。此外,外泌体可被用作药物传递的生物载体。系统性硬化症(systemic sclerosis, SSc)是一种复杂的自身免疫性疾病,发病机制包括血管损伤、免疫异常、内脏器官及皮肤纤维化。近年来,在研究 SSc 的发病机制方面取得了不错的进展,推动了临床治疗方面的研究。本文综述了外泌体的组成、功能,外泌体在 SSc 发病以及诊治方面的潜在作用。
Exosomes are small vesicles that can be secreted by most cells. Exosomes and their miRNA, mRNA and proteins play an important role in intercellular communication. Specifically, exosomes play an immunoregulatory role, participate in the pathogenesis and immunotherapy of autoimmune diseases, and can be used as effective biomarkers for diagnosis of diseases. In addition, exosomes can be used as biological carriers for drug delivery. Systemic sclerosis (SSc) is a complex autoimmune disease whose pathogenesis includes vascular damage, immune abnormalities, and fibrosis of internal organs and skin. In recent years, good progress has been made in the study of the pathogenesis of SSc, which has promoted research on clinical treatments. This article reviews the composition and function of exosomes, and their potential role in the pathogenesis, diagnosis and treatment of SSc.
丁甜甜,吕凤凤,赵巧英,孙晓林,王永福.外泌体在系统性硬化症中的研究进展[J].中国比较医学杂志,2022,32(9):115~121.
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