1.包头医学院第一附属医院中心实验室(内蒙古自治区自体免疫学重点实验室),内蒙古 包头 014010;2.包头医学院第一附属医院风湿免疫科,内蒙古 包头 014010
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1. Central Laboratory of Baotou Medical College, Key Laboratory of Autoimmunology, Baotou 014010, China.2. Department of Rheumatology, First Affiliated Hospital of Baotou Medical College, Baotou 014010
MicroRNAs(miRNAs)是一类内源性非编码小分子 RNA,长度为 20 ~ 23 个核苷酸。 MicroRNA-125(miR-125)是一个高度保守的 miRNA 家族,由 miR-125a、miR-125b-1 和 miR-125b-2 组成。越来越多的证据表明miR-125 参与体内的多种病理生理过程,调节包括免疫细胞在内的多种细胞的稳态和分化,与多种自身免疫性疾病密切相关,有望成为新的治疗靶点。本文综述了 miR-125 家族与自身免疫性疾病、免疫细胞的关系及其最新研究进展。
MicroRNAs ( miRNAs) are a class of endogenous non coding small RNA, with a length of 20 ~ 23 nucleotides. MicroRNA-125 (miR-125)is a highly conserved miRNA family, which is composed of miR-125a, miR-125b-1 and miR-125b-2. More and more evidences show that miR-125 participates in a variety of pathophysiological processes in vivo, regulates the homeostasis and differentiation of a variety of cells, including immune cells, and is closely related to a variety of autoimmune diseases, which is expected to become a new therapeutic target. This paper reviews the relationship between miR-125 family and autoimmune diseases and immune cells.
武志慧,孙晓林,王 慧. miRNA-125 家族与自身免疫性疾病关系的研究进展[J].中国比较医学杂志,2022,32(9):128~136.
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