基于中西医临床病症特点的乳腺癌动物模型分析
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河南中医药大学,郑州 450046

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R-33


Analysis of animal models of breast cancer based on clinical symptoms of Traditional Chinese and Western Medicine
Author:
Affiliation:

Henan University of Chinese Medicine, Zhengzhou 450046, China

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    摘要:

    目的 乳腺癌是我国女性发病率最高的恶性肿瘤,严重影响了患者的身心健康,制备出符合临床特征的乳腺癌动物模型,对研究乳腺癌的发病机制和治疗方案至关重要。 方法 以“乳腺癌”“动物模型”为主题,检索知网、万方、维普和 PubMed 数据库,以乳腺癌模型中西医临床诊断标准为依据,将现有乳腺癌动物模型的品种、特征、造模方法进行总结,根据乳腺癌的中西医临床病症特点进行吻合度评价。 结果 发现现有的动物模型制备方法较单一,大多以化药致癌造模方法为主,忽略了中医病因,缺少中医病症结合模型,与临床中多因素致病存在较大出入,限制了中医药防治乳腺癌相关研究和临床应用。 结论 乳腺癌模型评价以病理学诊断和瘤株(体)的形成为主,与临床中、西医乳腺癌诊断标准存在一定差异。 因此,有必要进一步完善乳腺癌动物模型评价体系,改进现有模型,使中医药基础研究更加贴合临床实际。

    Abstract:

    Objective Breast cancer is the malignant tumor with the highest incidence in women in China, which seriously affects the physical and mental health of patients. The preparation of animal models of breast cancer conforming to clinical characteristics is of great importance to the study of its pathogenesis and treatment. Methods Using “ breast cancer” and “animal model” as search terms, we searched China National Knowledge Infrastructure (CNKI),Wanfang, VIP and PubMed databases’ entries describing models of Chinese and Western Medicine clinical diagnostic criteria for breast cancer. We summarized breast cancer animal models of existing varieties, characteristics, and modeling method. Then we evaluated the consistency according to the clinical symptoms of Traditional Chinese and Western Medicine for breast cancer. Results We found that the existing animal model preparation method are relatively simple and mostly based on chemotherapy-induced cancer modeling method. Accordingly, these method ignore the etiology of Traditional Chinese Medicine and lack of combination model of Traditional Chinese Medicine disease. This result in large differences from clinical multi-factor disease observations, limiting research and clinical application of Traditional Chinese Medicine for the prevention and treatment of breast cancer. Conclusions Evaluation of breast cancer models is mainly based on pathological diagnosis and the formation of tumor strain (body), which is different from the Western and Chinese diagnostic criteria of breast cancer. Therefore, it is necessary to further improve the evaluation system of animal models of breast cancer, improve existing models, and make the basic research of Traditional Chinese Medicine more suitable for clinical practice.

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王 雪,张媛鑫,田 硕,彭孟凡,武香香,苗明三.基于中西医临床病症特点的乳腺癌动物模型分析[J].中国比较医学杂志,2022,32(9):137~144.

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  • 收稿日期:2021-11-01
  • 在线发布日期: 2023-01-16
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