1.河南中医药大学第一附属医院,郑州 450000;2.河南中医药大学儿科医学院,郑州 450000
R-33
1. the First Affiliated Hospital of Henan University of TCM, Zhengzhou 450000, China.2. Pediatric Medical College of Henan University of TCM, Zhengzhou 450000
过敏性紫癜(Henoch-Sch?nlein purpura,HSP)是儿童时期常见的全身性小血管炎病变,容易引起肾损伤,相较于本病大量临床研究报道,有关动物实验模型的文献报道相对较少。 现对比分析当前国内外 HSP 动物实验模型的构建机理、造模方法及优缺点,就 HSP 动物模型构建思路进行探讨分析,为本病的科学研究提供参考。
Henoch-Sch?nlein purpura (HSP) is a common systemic small vasculitis in childhood, which easily causes kidney damage. Compared with the large number of clinical studies on this disease, there are relatively few reports on animal models. Here, we systematically summarize the establishment, modeling method, advantages and disadvantages of the current domestic and foreign HSP animal models, expound the research status and existing problems of HSP animal models, and discuss and analyze the HSP animal model establishment to provide ideas and references for scientific research on this disease.
段凤阳,徐闪闪,丁 樱,郭 婷,宋纯东,张 霞.过敏性紫癜动物实验模型的对比分析及建模思路探讨[J].中国比较医学杂志,2022,32(10):104~108.
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