Cardio-oncology is a new interdisciplinary subject involving oncology and cardiovascular disease. With the rapid development of tumor treatment strategies, the survival of patients has been prolonged, and the side effects of treatments, especially cardiovascular toxicity, have received increasing attention. The establishment of an animal model of cardio-oncology is helpful to understand the pathogenesis of cardiovascular toxicity and take cardioprotective measures to prevent irreversible damage. Currently, non-tumor-bearing rodents are used in experiments. They are widely used, but there are few studies on animal modeling method . In this review, animal models of cardio-oncology established by antitumor treatments, such as chemotherapy, molecular targeted therapy, and radiotherapy, in recent years were collected and sorted, and the advantages and disadvantages of various animal models and modeling method were summarized. This article reviews the aspects of the developing clinical cardio-oncology and provides insights for the development of clinical cardiooncology.