肠道菌群在抑郁症发生中的调控机制研究进展
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作者单位:

1.山西医科大学实验动物中心,实验动物与人类疾病动物模型山西省重点实验室,太原 030001;2.山西医科大学精神卫生学院,太原 030001

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R-33


Research progress on the regulatory mechanism of intestinal flora in the occurrence of depression
Author:
Affiliation:

1. Laboratory Animal Center, Shanxi Key Laboratory of Experimental Animal Science and Animal Model of Human Disease,Shanxi Medical University, Taiyuan 030001, China. 2. School of Mental Health, Shanxi Medical University,Taiyuan 030001

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    摘要:

    抑郁症已成为最常见的精神疾病,其发病率逐年上升,病因尚不明确,因此,迫切需要探索抑郁症的发病机制,继而寻找相应的治疗手段。 近年来,随着抑郁症相关研究的不断增加,肠道菌群成为抑郁症发病机制研究的新热点,其能够通过多种途径直接或间接地影响大脑的功能,调节压力、焦虑和抑郁等行为。 本综述就肠道菌群与抑郁症动物模型实验研究和临床实验研究的联系、肠道菌群在抑郁症发生发展中的可能调控机制和益生菌的抗抑郁作用机制进行阐述,以期为肠道菌群治疗抑郁症提供新的理论依据。

    Abstract:

    Depression has become the most common mental illnesses. Its incidence is increasing yearly and the cause remains unclear. Therefore, it is urgent to explore the pathogenesis of depression and find treatments. In recent years with the continuous increase of research related to depression, intestinal flora have become a new research hotspot in the pathogenesis of depression. Intestinal flora directly and indirectly affect brain functions through various mechanisms and regulate behaviors such as stress, anxiety and depression. This review discusses the relationship between intestinal flora and studies of animal models and clinical depression, the possible regulatory mechanism of intestinal flora in the occurrence and development of depression, and the anti-depressant mechanism of probiotics to provide a new theoretical basis for the treatment of depression by intestinal flora.

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陈文璐,闫晓如,高继萍,宋国华.肠道菌群在抑郁症发生中的调控机制研究进展[J].中国比较医学杂志,2022,32(10):130~135.

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  • 收稿日期:2021-09-03
  • 在线发布日期: 2023-05-08
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