Psoriasis is a chronic inflammatory skin disease with a polygenic genetic background. Disorder of the immune system is the cause of the development and persistence of psoriasis inflammation. It is believed that overactivation of the IL-23 / Th17 axis is the main pathogenesis of psoriasis. Psoriasis is mainly characterized by erythema, scale, and infiltration, and some patients have recurrent attacks, which cause psychological and economic burdens to individuals. The 2018 edition of the Chinese guidelines for the diagnosis and treatment of psoriasis indicated that the basic syndrome types of psoriasis are blood-heat syndrome, blood stasis syndrome, blood dryness syndrome, heat-toxin syndrome, dampness-heat accumulation syndrome, and rheumatism obstruction syndrome. Clinical treatment needs to be based on the syndrome types of dialectical treatment. Therefore, the disease and syndrome of psoriasis combined with an animal model is an important basis to study traditional Chinese medicine in the treatment of psoriasis. There are many psoriasis models, but a combination of disease and syndrome animal model has not been established, which cannot fully and comprehensively reflect the performance of a traditional Chinese medicine syndrome. This review summarizes the existing disease-syndrome combination models to provide comprehensive basic support for the research of syndrome differentiation and treatment of psoriasis.