Beta 属冠状病毒亚基因组检测及应用进展

doi:10. 3969 / j.issn.1671-7856. 2022. 11. 019

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Beta 属冠状病毒亚基因组检测及应用进展
DOI:
                        10. 3969 / j.issn.1671-7856. 2022. 11. 019
                    
作者:
                        张亚青张亚青
中国医学科学院医学实验动物研究所,北京协和医学院比较医学中心,国家卫生健康委员会人类疾病比较医学重点实验室,新发再发传染病动物模型研究北京市重点实验室,北京市人类重大疾病实验动物模型工程技术研究中心,国家中医药管理局人类疾病动物模型三级实验室,北京 100021
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戚菲菲戚菲菲
中国医学科学院医学实验动物研究所,北京协和医学院比较医学中心,国家卫生健康委员会人类疾病比较医学重点实验室,新发再发传染病动物模型研究北京市重点实验室,北京市人类重大疾病实验动物模型工程技术研究中心,国家中医药管理局人类疾病动物模型三级实验室,北京 100021
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鲍琳琳鲍琳琳
中国医学科学院医学实验动物研究所,北京协和医学院比较医学中心,国家卫生健康委员会人类疾病比较医学重点实验室,新发再发传染病动物模型研究北京市重点实验室,北京市人类重大疾病实验动物模型工程技术研究中心,国家中医药管理局人类疾病动物模型三级实验室,北京 100021
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作者单位:中国医学科学院医学实验动物研究所,北京协和医学院比较医学中心,国家卫生健康委员会人类疾病比较医学重点实验室,新发再发传染病动物模型研究北京市重点实验室,北京市人类重大疾病实验动物模型工程技术研究中心,国家中医药管理局人类疾病动物模型三级实验室,北京 100021
作者简介:
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中图分类号:R-33
基金项目:

Research progress on subgenome of beta-coronavirus

Author:

ZHANG Yaqing
ZHANG Yaqing
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center,Peking Union Medical Collage (PUMC);NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Key Laboratory for Animal Models of Emerging and Reemerging Infectious;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases;Key Laboratory of Human Diseases Animal Model, State Administration of Traditional Chinese Medicine, Beijing 100021, China
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QI Feifei
QI Feifei
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center,Peking Union Medical Collage (PUMC);NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Key Laboratory for Animal Models of Emerging and Reemerging Infectious;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases;Key Laboratory of Human Diseases Animal Model, State Administration of Traditional Chinese Medicine, Beijing 100021, China
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BAO Linlin
BAO Linlin
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center,Peking Union Medical Collage (PUMC);NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Key Laboratory for Animal Models of Emerging and Reemerging Infectious;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases;Key Laboratory of Human Diseases Animal Model, State Administration of Traditional Chinese Medicine, Beijing 100021, China
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Affiliation:

Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center,Peking Union Medical Collage (PUMC);NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Key Laboratory for Animal Models of Emerging and Reemerging Infectious;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases;Key Laboratory of Human Diseases Animal Model, State Administration of Traditional Chinese Medicine, Beijing 100021, China

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摘要:

目前已知可以感染人类的冠状病毒(coronavirus)有 7 种,其中 Beta 冠状病毒属( beta coronavirus)有5 种。人冠状病毒 OC43(human coronavirus OC43,HCoV-OC43)、人冠状病毒 HKU1(human coronavirus HKU1,HCoVHKU1)感染呈现季节性特征, 症状轻微。严重急性呼吸综合征冠状病毒 ( severe acute respiratory syndrome coronavirus,SARS-CoV)、中东呼吸综合征冠状病毒(middle east respiratory syndrome coronavirus,MERS-CoV)和严重急性呼吸综合征冠状病毒 2(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)感染后迅速在人与人之间传播,病毒流行对公共卫生安全和国民经济造成严重威胁。核酸检测是鉴别、诊断和排查病毒感染患者的关键检测方法之一,但核酸阳性并不意味着病毒具有传染性,需要探索一种快速反应病毒复制能力的检测方法作为补充。研究证实 Beta 属冠状病毒在细胞复制过程中产生的亚基因组(subgenomic RNA,sgRNA)可以作为判断病毒活性的指标。本文对 Beta 属冠状病毒亚基因组的检测应用等进行综述,旨在建立亚基因组检测方法,优化病毒检测方式,完善实验室动物模型创建及药物疫苗有效性评价体系,助力开展实验研究。

关键词:Beta 属冠状病毒;亚基因组;病毒复制;检测方法

Abstract:

Five of seven coronaviruses that cause respiratory disease in humans were beta-coronaviruses. HCoVOC43 and HCoV-HKU1 show seasonal transmission and cause mild symptoms after infection. SARS-CoV, MERS-CoV and SARS-CoV-2 spread rapidly from person to person, which posed a serious threat to public health security and national economy. Nucleic acid testing is the key test to identify, diagnose and screen people infected by virus, but the positive of viral loads does not mean the virus is contagious. It is urgenly to explore a rapid detecting method for virus replication as a supplement to judge virus activity. Studies have confirmed that the subgenomes produced by beta-coronaviruses during cell replication can be used as indicators for judging viral activity. This paper reviews the detection and application of subgenomes of beta-coronavirus, aiming to establish subgenome detection method , optimize virus detection method , perfect experimental animal model creation and drug or vaccine effectiveness evaluation systems and help to carry out experimental research.

Key words:beta coronavirus; subgenome; virus replication; detection method

引用本文

张亚青,戚菲菲,鲍琳琳. Beta 属冠状病毒亚基因组检测及应用进展[J].中国比较医学杂志,2022,32(11):142~148.

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收稿日期:2022-04-20
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在线发布日期: 2023-01-18
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