Cervical intraepithelial neoplasia is mostly treated by surgery, and clinically specific drugs are lacking. Although surgery can remove transformed lesions, the stump has the risk of lesions under the continuous action of viruses and other factors. Therefore, prevention and treatment of CIN require suitable animal models. Cervical lesions usually manifest as a series of continuous processes, and this progressive pathological process makes it difficult to replicate in animal models. Research on the establishment of CIN animal models at home and abroad has gradually increased in recent years. This review discusses the development method, advantages, and disadvantages of CIN mouse models to provide ideas for the establishment of more suitable animal models and long-term prevention and treatment of cervical intraepithelial neoplasia. Strategy and drug research to provide assistance.