烟雾刺激法诱导呼吸系统疾病动物模型的研究及应用进展
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作者单位:

广西中医药大学,南宁 530200

中图分类号:

R-33


Research and application progress of animal models of respiratory diseases induced by the smoke stimulation method
Author:
Affiliation:

Guangxi University of Chinese Medicine, Nanning 530200, China

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    摘要:

    环境空气污染对人类呼吸系统造成了严重的损害,增加了罹患呼吸系统疾病的风险。烟雾刺激法是临床动物实验中常用于制备呼吸系统疾病动物模型的造模方法,包括香烟烟雾刺激和浓烟烟雾刺激,主要是模仿空气环境污染的致病原理进行动物模型的制备。通过在动物模型上实施药物干预,是研发治疗呼吸系统疾病以及减轻疾病症状药物的关键。当前阶段,中药或中医外治对于治疗呼吸系统疾病的作用机制研究不断深入,中医药疗法在治疗呼吸系统疾病方面具有独特的优势。因此,构建出与临床呼吸系统疾病重现性好、吻合度高的动物模型,对于防治和研究呼吸系统疾病尤为重要。该文主要从环境空气污染对人类呼吸系统造成的危害入手,阐述烟雾刺激法的致病机制以及动物模型制备要素和方法,并分析烟雾刺激法构建的动物模型在中药和中医外治当中的应用,为构建更加合理的呼吸系统疾病动物模型及中医新疗法和新药物的出现奠定基础。

    Abstract:

    Environmental air pollution causes serious damage to the human respiratory system and increases the risk of respiratory diseases. Smoke stimulation is a modeling method commonly used in clinical animal experiments to prepare animal models of respiratory diseases, including cigarette smoke stimulation and thick smoke stimulation, by imitating the pathological principle of air environmental pollution. Through drug treatment of animal models, researchers can develop drugs to treat respiratory diseases and alleviate symptoms. Research on the mechanism of traditional Chinese medicine and external treatment with traditional Chinese medicine for respiratory diseases is constantly progressing. Traditional Chinese medicine therapy has unique advantages in the treatment of respiratory diseases. Therefore, establishing an animal model with good reproducibility and high consistency with clinical respiratory diseases is particularly important to prevent, treat, and research respiratory diseases. This article mainly discusses harm caused by environmental air pollution to the human respiratory system, expounds the pathological mechanism of the smog stimulation method and the preparation elements and method of animal models, and analyzes the application of animal models established by the smog stimulation method in traditional Chinese medicine and external treatment with traditional Chinese medicine, laying the foundation to establish more reasonable animal models of respiratory diseases and the emergence of new therapies and drugs in traditional Chinese medicine.

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邓亚胜,林 江,黄 慧,梁天薇,荣 娜,郑艺清,范燕萍.烟雾刺激法诱导呼吸系统疾病动物模型的研究及应用进展[J].中国比较医学杂志,2023,33(5):118~126.

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  • 收稿日期:2022-11-10
  • 在线发布日期: 2023-06-15
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