Depression is a disease that seriously endangers human physical and mental health. The establishment of a suitable animal model of depression is of great significance to study its pathogenesis and develop drugs. Among the animal models of depression, animal models of drug-induced depression are widely used because of the advantages of simplicity and timely establishment. This article systematically reviewed drug-induced depression animal models in the China National Knowledge Network and PubMed until July 1, 2021, and reviewed six commonly used drug-induced depression animal models. The frequency of use of induced depression animal models, selection of model animals, drug injection dosage, injection method , indicators for model evaluation, advantages, and disadvantages are expected to provide references to prepare depression models and develop drugs.