肠道菌群失调与自闭症谱系障碍的相关性研究进展
作者:
作者单位:

1.大理大学药学院,云南 大理 671000;2.云南省昆虫生物医药研发重点实验室,云南 大理 671000; 3.药用特种昆虫开发国家地方联合工程研究中心,云南 大理 671000;4.湘潭医卫职业技术学院,湖南 湘潭 411104; 5.大理大学公共卫生学院,云南 大理 671000

中图分类号:

R-33


Research progress on the correlation between gut microbiota and autism spectrum disorders
Author:
  • DONG Lixian 2,3,5,1,4

    DONG Lixian

    1. College of Pharmacy, Dali University, Dali 671000, China. 2. Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali University, Dali 671000. 3. National Joint Engineering Research Center for the Development of Medicinal Special Insects, Dali University, Dali 671000.
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  • YIN Aiwu 2,3,5,1,4

    YIN Aiwu

    4. Xiangtan Medicine and Health Vocational College, Xiangtan 411104.
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  • LI Canwei

    LI Canwei

    2. Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali University, Dali 671000. 3. National Joint Engineering Research Center for the Development of Medicinal Special Insects, Dali University, Dali 671000. 4. Xiangtan Medicine and Health Vocational College, Xiangtan 411104. 5. College of Public Health, Dali University, Dali 671000
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  • FAN Mengran 2,3,5,1,4

    FAN Mengran

    2. Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali University, Dali 671000. 3. National Joint Engineering Research Center for the Development of Medicinal Special Insects, Dali University, Dali 671000. 4. Xiangtan Medicine and Health Vocational College, Xiangtan 411104.
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  • WU Xiumei

    WU Xiumei

    2. Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali University, Dali 671000. 3. National Joint Engineering Research Center for the Development of Medicinal Special Insects, Dali University, Dali 671000. 4. Xiangtan Medicine and Health Vocational College, Xiangtan 411104. 5. College of Public Health, Dali University, Dali 671000
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  • YANG Zizhong 2,3,5,1,4

    YANG Zizhong

    1. College of Pharmacy, Dali University, Dali 671000, China. 2. Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali University, Dali 671000. 3. National Joint Engineering Research Center for the Development of Medicinal Special Insects, Dali University, Dali 671000.
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  • ZHANG Chenggui 2,3,5,1,4

    ZHANG Chenggui

    1. College of Pharmacy, Dali University, Dali 671000, China. 2. Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali University, Dali 671000. 3. National Joint Engineering Research Center for the Development of Medicinal Special Insects, Dali University, Dali 671000.
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  • GAO Pengfei 2,3,5,1,4

    GAO Pengfei

    1. College of Pharmacy, Dali University, Dali 671000, China. 2. Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali University, Dali 671000. 3. National Joint Engineering Research Center for the Development of Medicinal Special Insects, Dali University, Dali 671000.
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Affiliation:

1. College of Pharmacy, Dali University, Dali 671000, China. 2. Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali University, Dali 671000. 3. National Joint Engineering Research Center for the Development of Medicinal Special Insects, Dali University, Dali 671000. 4. Xiangtan Medicine and Health Vocational College, Xiangtan 411104. 5. College of Public Health, Dali University, Dali 671000

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    摘要:

    自闭症谱系障碍(autism spectrum disorder,ASD)是一种神经发育障碍性疾病,因其发病率持续上升,引起了全球的关注。研究发现,肠道菌群(gut microbiota)与ASD 之间有一定的关联性,体内动态平衡的肠道菌群可以保证人体正常的生命活动,但当其失去稳态时可能会通过改变神经递质、代谢物、免疫系统、HPA 轴和肠道通透性等影响ASD 的发生发展。益生菌、益生元以及粪菌移植等肠道菌群干预对于治疗ASD 有一定效果。中医药也可通过干预肠道菌群达到一定的治疗ASD 的目的。本文旨在通过总结肠道菌群紊乱影响ASD 的机制,为ASD的研究和治疗提供参考。

    Abstract:

    Autism spectrum disorder(ASD) is a kind of neurodevelopmental disorder that has attracted global attention because of its continued rise in incidence. There is a correlation between gut microbiota and ASD. Homeostasis of gut microbiota ensures normal life activities and may affect the occurrence and development of ASD through changing neurotransmitters, metabolites, the immune system, HPA axis, and intestinal permeability by losing its homeostasis. Gut microbiota treatment method, such as probiotics, prebiotics, and fecal microbiota transplantation, have a treatment effects on ASD. Additionally, traditional Chinese medicine may exert a certain treatment effect on ASD by through gut microbiota. The purpose of this review was to summarize the mechanism of gut microbiota disturbance affecting ASD as well as related research method and models to provide reference for the research and treatment of ASD.

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引用本文

董丽仙,尹爱武,李灿委,范孟然,巫秀美,杨自忠,张成桂,高鹏飞.肠道菌群失调与自闭症谱系障碍的相关性研究进展[J].中国比较医学杂志,2023,33(6):95~101.

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  • 收稿日期:2022-08-19
  • 在线发布日期: 2023-08-18
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