Objective To evaluate the feasibility of an animal model of simulated adenoid hypertrophy by combining animal models of allergic rhinitis and chronic pharyngitis. Methods A rat model of allergic rhinitis was established by basal sensitization through intraperitoneal OVA injection and nasal enhanced sensitization. A model of chronic pharyngitis was established simultaneously by a throat spray of ammonia, both models were combined into a rat model of simulated adenoid hypertrophy. The symptom performance of model animals was assessed by the animal behavioral score after modeling. Pathomorphological changes of nasal and pharyngeal mucosae and nasopharyngeal lymph nodes were observed by HE staining. The percentage of eosinophils was assess in rat whole blood. IL-4 and IgE levels in rat serum and mucosal tissue were measured by ELISA. Results The behavior score, eosinophil percentage, and IL-4 and IgE levels in serum and tissue were increased compared with the control group (P< 0. 01). Compared with model group A, the eosinophil percentage and serum IgE level were increased in model group B (P<0. 01). In the model groups, nasal and pharyngeal mucosae and nasopharyngeal lymph nodes showed different degrees of disease-related histopathological changes. Conclusions The rat model had symptom manifestations and pathological changes similar to adenoid hypertrophy. This animal model of simulated adenoid hypertrophy can be used as a combined animal model of allergic rhinitis and chronic pharyngitis, but requires further exploration and improvement.