川芎嗪-丹参配伍前后在急性心肌缺血模型大鼠体内的组织分布差异研究

doi:10. 3969 / j.issn.1671-7856. 2023. 09 002

首页 > 过刊浏览>2023年第33卷第9期 >8-15. DOI:10. 3969 / j.issn.1671-7856. 2023. 09 002

川芎嗪-丹参配伍前后在急性心肌缺血模型大鼠体内的组织分布差异研究
DOI:
                        10. 3969 / j.issn.1671-7856. 2023. 09 002
                    
作者:
                        李 容李 容
1.贵州医科大学 贵州省药物制剂重点实验室 省部共建药用植物功效与利用国家重点实验室,贵阳 550004;3.贵州医科大学 药学院,贵阳 550004
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勾 健勾 健
1.贵州医科大学 贵州省药物制剂重点实验室 省部共建药用植物功效与利用国家重点实验室,贵阳 550004;3.贵州医科大学 药学院,贵阳 550004
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刘 亭2,3,1刘 亭
2.贵州医科大学 民族药与中药开发应用教育部工程研究中心,贵阳 550004;
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巩仔鹏2,3,1巩仔鹏
1.贵州医科大学 贵州省药物制剂重点实验室 省部共建药用植物功效与利用国家重点实验室,贵阳 550004;
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陆 苑2,3,1陆 苑
1.贵州医科大学 贵州省药物制剂重点实验室 省部共建药用植物功效与利用国家重点实验室,贵阳 550004;
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刘春花2,3,1刘春花
2.贵州医科大学 民族药与中药开发应用教育部工程研究中心,贵阳 550004;
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黄 勇2,3,1黄 勇
1.贵州医科大学 贵州省药物制剂重点实验室 省部共建药用植物功效与利用国家重点实验室,贵阳 550004;
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孙 佳2,3,1孙 佳
1.贵州医科大学 贵州省药物制剂重点实验室 省部共建药用植物功效与利用国家重点实验室,贵阳 550004;
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作者单位:1.贵州医科大学 贵州省药物制剂重点实验室 省部共建药用植物功效与利用国家重点实验室,贵阳 550004;2.贵州医科大学 民族药与中药开发应用教育部工程研究中心,贵阳 550004;3.贵州医科大学 药学院,贵阳 550004
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中图分类号:R-33
基金项目:

Tissue distribution of ligustrazine-Salvia miltiorrhiza before and after compatibility in acute myocardial ischemia model rats

Author:

LI Rong
LI Rong
1. Guizhou Provincial Key Laboratory of Pharmaceutics, State Key Laboratory of Efficacy and Utilization of Medicinal Plants, Guizhou Medical University, Guiyang 550004, China.3. School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550004
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GOU Jian
GOU Jian
1. Guizhou Provincial Key Laboratory of Pharmaceutics, State Key Laboratory of Efficacy and Utilization of Medicinal Plants, Guizhou Medical University, Guiyang 550004, China.3. School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550004
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LIU Ting ^{^2,3,1}
LIU Ting
2. Ministry of Education Engineering Research Center for Ethnic Medicine and Traditional Chinese Medicine Development and Application, Guizhou Medical University, Guiyang 550004.
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GONG Zipeng ^{^2,3,1}
GONG Zipeng
1. Guizhou Provincial Key Laboratory of Pharmaceutics, State Key Laboratory of Efficacy and Utilization of Medicinal Plants, Guizhou Medical University, Guiyang 550004, China.
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LU Yuan ^{^2,3,1}
LU Yuan
1. Guizhou Provincial Key Laboratory of Pharmaceutics, State Key Laboratory of Efficacy and Utilization of Medicinal Plants, Guizhou Medical University, Guiyang 550004, China.
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LIU Chunhua ^{^2,3,1}
LIU Chunhua
2. Ministry of Education Engineering Research Center for Ethnic Medicine and Traditional Chinese Medicine Development and Application, Guizhou Medical University, Guiyang 550004.
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HUANG Yong ^{^2,3,1}
HUANG Yong
1. Guizhou Provincial Key Laboratory of Pharmaceutics, State Key Laboratory of Efficacy and Utilization of Medicinal Plants, Guizhou Medical University, Guiyang 550004, China.
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SUN Jia ^{^2,3,1}
SUN Jia
1. Guizhou Provincial Key Laboratory of Pharmaceutics, State Key Laboratory of Efficacy and Utilization of Medicinal Plants, Guizhou Medical University, Guiyang 550004, China.
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Affiliation:

1. Guizhou Provincial Key Laboratory of Pharmaceutics, State Key Laboratory of Efficacy and Utilization of Medicinal Plants, Guizhou Medical University, Guiyang 550004, China. 2. Ministry of Education Engineering Research Center for Ethnic Medicine and Traditional Chinese Medicine Development and Application, Guizhou Medical University, Guiyang 550004. 3. School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550004

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摘要:

目的对盐酸川芎嗪与丹参配伍前后在急性心肌缺血(acute myocardial ischemia,AMI)模型大鼠体内的组织分布差异进行探讨。方法大鼠皮下注射盐酸异丙肾上腺素溶液复制AMI 模型,分为川芎嗪组(ligustrazine,LG)、丹参组(Danshen,DS)和川芎嗪-丹参组(ligustrazine-Danshen,LD),采用UPLC-MS/ MS方法测定不同时间点下川芎嗪和丹参素2 种活性成分在心脏、肝、脾、肺、肾、脑组织中的含量差异。结果注射后川芎嗪和丹参素在AMI 大鼠各组织中分布广泛且迅速达峰;配伍前后,各组川芎嗪在脑组织中含量最高,在肝组织中含量最低;丹参素在肾组织中含量最高,在脑组织中含量最低,表明川芎嗪较丹参素更易透过血脑屏障,且主要蓄积组织有所差异;而配伍用药显著增加了川芎嗪和丹参素在靶器官心脏中的AUC(P<0. 001)。结论推测川芎嗪与丹参配伍可能是通过增加主要药效成分在心脏中的分布增强治疗作用,进而能更好地发挥药效。

关键词:川芎嗪-丹参;配伍;组织分布;差异

Abstract:

Objective To investigate the difference in tissue distribution of ligustrazine hydrochloride and Salvia miltiorrhiza (Danshen) in acute myocardial ischemia (AMI) model rats. Methods A rat model of AMI was induced by subcutaneous injection of isoproterenol hydrochloride solution. The rats were then divided into a ligustrazine group, Danshen group, and ligustrazine-Danshen group. Ligustrazine and Danshensu levels in the heart, liver, spleen, lung, kidney, and brain were detected at different time points by ultra-high performance liquid chromatography/ tandem mass spectrometry. Results Ligustrazine and Danshensu were widely distributed and peaked rapidly in tissues of AMI rats after intravenous injection. Before and after compatibility, the content of ligustrazine was highest in brain tissue and lowest in liver tissue, while the Danshensu content was highest in kidney tissue and lowest in brain tissue, indicating that ligustrazine could penetrate the blood-brain barrier more easily than Danshensu, and the main sites of accumulation were different. The areas under the curves of ligustrazine and Danshensu in the heart as the target organ were significantly increased (P<0. 001). Conclusions These result suggest that the combination of ligustrazine and Danshen may enhance the therapeutic effect by increasing the distribution of the main pharmacodynamic components in the heart, thus improving the efficacy.

Key words:ligustrazine-Salvia miltiorrhiza; compatibility; tissue distribution; difference

引用本文

李容,勾健,刘亭,巩仔鹏,陆苑,刘春花,黄勇,孙佳.川芎嗪-丹参配伍前后在急性心肌缺血模型大鼠体内的组织分布差异研究[J].中国比较医学杂志,2023,33(9):8~15.

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收稿日期:2023-02-10
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在线发布日期: 2023-11-09
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