平顶山学院医学院基础医学系,河南 平顶山 467000
R-33
Department of Basic Medicine, Medical College, Pingdingshan University, Pingdingshan 467000, China
外泌体作为一种能被不同细胞分泌的小分子细胞外囊泡,通过运输miRNA 等多种生物活性物质在阿尔茨海默病(Alzheimer’s disease,AD)的病理过程中发挥重要作用。研究表明,外泌体miRNA 的表达在AD 患者早期阶段发生变化,并且通过外源性注射间充质干细胞来源的外泌体miRNA 可以改善AD 动物模型的学习记忆能力。本文就该领域对外泌体在早期筛查和治疗AD 的研究情况进行综述。
Exosomes are small molecule extracellular vesicles secreted by various cells and play a major role in the pathological process of Alzheimer’s disease by transporting various bioactive substances such as miRNAs. Expression of exosomal miRNA changes in the early stages of AD, and exogenous injection of mesenchymal stem cell-derived exosomal miRNA improves learning and memory of AD animal models. This article reviews the research progress of exosomes in early screening and treatment of Alzheimer’s disease.
张俊峰,郝丽亚,高红艳,刘光甫,张祖源,郭永刚.外泌体miRNA 在早期筛查与治疗阿尔茨海默病的相关研究进展[J].中国比较医学杂志,2023,33(10):140~145.
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