1.昆明理工大学灵长类转化医学研究院,省部共建非人灵长类生物医学国家重点实验室,昆明 650500; 2.云南中科灵长类生物医学重点实验室,昆明 650500
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1.State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650500, China. 2. Yunnan Province Key Laboratory of Primate Biomedicine, Kunming 650500
帕金森病(Parkinson’s disease,PD)是一种神经退行性疾病,目前发病机制不明,患者会出现与疾病相关的运动和非运动症状。啮齿类动物模型只能部分精准模拟患者的症状,导致相关的临床前研究存在局限性,非人灵长类动物模型能够较好的弥补这种缺陷,对非人灵长类PD 模型的运动和非运动症状的量化有利于发病机制和治疗的研究,本综述中总结了不同行为学量化方式,同时对比了不同方法之间的优劣性,为进行PD 猴模型研究提供了行为学测试的参考。
Parkinson’ s disease (PD) is a neurodegenerative disease. Its pathogenesis is currently unknown. Patients may present with motor and non-motor symptoms. To explore the mechanisms underlying these phenotypes, appropriate animal models are needed. Rodent models only partially recapitulate the symptoms of PD. Therefore, relevant preclinical studies are limited. Non-human primate animal models are better able to recapitulate such symptoms. Quantifying motor and non-motor symptoms in non-human primate models of PD is useful to study its pathogenesis and treatment. This review summarizes various approaches to quantifying behavioral paradigms and compares the advantages and disadvantages of the approaches. It also provides a reference for behavioral testing in PD monkey models.
刘书一,王正波.非人灵长类帕金森动物模型中的行为学评估[J].中国比较医学杂志,2023,33(11):96~103.
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