1.内蒙古科技大学包头医学院,内蒙古 包头 014010;2.内蒙古科技大学包头医学院第一附属医院风湿免疫科,内蒙古 包头 014010;3.内蒙古科技大学包头医学院第一附属医院中心实验室(内蒙古自治区自体免疫学重点实验室),内蒙古 包头 014010
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WANG Yongfu
2.Department of Rheumatology, the First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014010. 3.Central Laboratory of the First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology (Key Laboratory of Autoimmunity of Inner Mongolia), Baotou 0140101.Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014010, China.2.Department of Rheumatology, the First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014010. 3.Central Laboratory of the First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology (Key Laboratory of Autoimmunity of Inner Mongolia), Baotou 014010
系统性硬化症(systemic sclerosis,SSc)是一种以血管病变、皮肤纤维化为特征,可引起多器官结构和功能损害的自身免疫性疾病,SSc 发病机制复杂,可能与遗传、环境因素、免疫机制异常等有关。自噬是一种在进化上保守的机体内自降解过程,可通过多种途径参与机体免疫及自身免疫性疾病发病。本文主要综述自噬通过调节免疫细胞、介导信号通路调控SSc 血管病变和纤维化的研究进展。
Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular lesions and skin fibrosis, which causes structural and functional damage to multiple organs. The pathogenesis of SSc is complex and may be related to genetic and environmental factors as well as abnormal immune mechanisms. Autophagy is an evolutionarily conserved process of self-degradation in the body and participates in the pathogenesis of autoimmune diseases through various pathways. This article reviews the research progress on the role of autophagy in the angiopathy and fibrosis of SSc by regulating immune cells and mediating signaling pathways.
李鑫,孙晓林,王永福.自噬在系统性硬化症发病机制中作用的研究进展[J].中国比较医学杂志,2023,33(12):97~103.
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