鸢尾素及其上下游抗抑郁的研究进展
作者:
作者单位:

1.天津中医药大学实验针灸学研究中心,天津 301617;2.天津中医药大学针灸推拿学院,天津 301617;3.天津中医药大学医学技术学院,天津 301617

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R-33


Progress in irisin and its upstream and downstream antidepressants
Author:
Affiliation:

1. Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China. 2. School of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin 301617. 3. School of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin 301617

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    摘要:

    抑郁症是主要的致残原因之一,对人们带来不利影响。尽管抗抑郁药种类较多,但临床上抑郁症治疗效果依然欠佳。因此,目前仍需要探索新的抗抑郁机制。鸢尾素对神经系统的有益作用逐渐被阐明,研究发现鸢尾素具有抗抑郁的作用,其或将成为治疗抑郁症的新靶点。本研究旨在探讨鸢尾素及其上下游抗抑郁的作用机制,通过查阅现有的研究阐释鸢尾素与抑郁症之间的联系,提出SIRT1/ PGC-1α 可能介导FNDC5/ 鸢尾素调控脑源性神经营养因子(BDNF)促进神经发生,改善抑郁症的潜在机制,为鸢尾素及其上下游抗抑郁的研究提供新思路。

    Abstract:

    Depression is a major cause of disability and has adverse effects. Despite the many types of antidepressants, clinical treatments of depression remain poor. Therefore, novel anti-depressant mechanisms need to be explored. The beneficial effects of irisin on the nervous system are gradually being elucidated, and studies have found that irisin has an anti-depressant effect, which may become a new treatment for depression. This study explored the mechanism of irisin and its upstream and downstream anti-depressants by reviewing the existing studies explaining the link between irisin and depression, and proposes that SIRT1/ PGC-1α may mediate FNDC5/ irisin to regulate BDNF to promote neurogenesis and improve depression, which provides a new idea to study irisin and its upstream and downstream antidepressants.

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桑加拉,李姗姗,崔 鑫,任晴晴,侯瑞铃,潘兴芳,王慎军,赵美丹.鸢尾素及其上下游抗抑郁的研究进展[J].中国比较医学杂志,2024,34(1):130~138.

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  • 收稿日期:2023-03-27
  • 在线发布日期: 2024-03-04
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