PD is a neurodegenerative disease characterized by degenerative death of dopaminergic neurons in the substantia nigra, exhibiting a range of motor and non-motor symptoms with serious effects on quality of life. circRNA is a covalently closed-loop non-coding RNA that plays a major role in PD progression. This article reviews the involvement of circRNA in oxidative stress, regulation of transcription, neuroinflammation, autophagy, and α-synuclein.