TRP 通道介导线粒体功能调控及其与心血管疾病关系研究进展
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三峡大学国家中医药管理局中药药理科研三级实验室,三峡大学基础医学院,湖北 宜昌 443000

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R-33


Progress of research into mitochondria functional regulation by transent receptor potential channels and its relevance to cardiovascular diseases
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Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, Medical College, China Three Gorges University, Yichang 443000, China

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    摘要:

    瞬时受体电位(transient receptor potential,TRP)通道是一类非选择性阳离子通道。 近年来研究发现TRP 通道与多种疾病有关,其中关于 TRP 通道通过线粒体功能调控参与相关心血管疾病机制的研究,正成为心血管疾病机制研究的热点之一。 目前相关的文献主要集中在 TRPV、TRPM 和 TRPC。 本文主要就上述 3 种 TRP 通道在线粒体功能调节中的作用及其与心血管疾病的关系研究进展进行综述。

    Abstract:

    Transent receptor potential(TRP) channels are non-selective cation channels. In recent years, a large number of studies have found that TRP channels participate in a variety of cardiovascular diseases. How mitochondrial function is regulated by TRP channels and the relationship to cardiovascular diseases have become research hotspots. Up to now, related studies have mainly focused on TRPV, TRPM, and TRPC channels. This review focuses on the roles of the above TRP channels in the regulation of mitochondrial function and their relationships to cardiovascular diseases.

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朱美萍,张世忠. TRP 通道介导线粒体功能调控及其与心血管疾病关系研究进展[J].中国比较医学杂志,2024,34(3):127~132.

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  • 收稿日期:2023-05-14
  • 在线发布日期: 2024-05-29
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