中医药调控谷氨酸治疗抑郁症的研究进展
作者:
作者单位:

1.华北理工大学中医学院,河北 唐山 063210;2.河北省中西医结合防治糖尿病及其并发症重点实验室,河北 唐山 063210

中图分类号:

R-33


Research progress on the regulation of glutamate in traditional Chinese medicine for treatment of depression
Author:
Affiliation:

1. College of Traditional Chinese Medicine of North China University of Science and Technology, Tangshan 063210, China.2. Hebei Key Laboratory of Integrated Traditional Chinese and Western Medicine for Diabetes and Its Complications, Tangshan 063210

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    摘要:

    谷氨酸是中枢神经系统中主要的兴奋性神经递质,也是潜在的神经毒素。 在抑郁症发生发展过程中存在海马区谷氨酸浓度升高的现象,谷氨酸发生堆积时,将对神经元和脑组织造成严重损伤,加重抑郁状态。 因此谷氨酸堆积可能是造成抑郁症的重要机制。 星形胶质细胞、谷氨酸转运体及谷氨酸受体对谷氨酸的浓度起着重要的调控作用。 本文综述了中医药疗法通过调控星形胶质细胞、谷氨酸转运体、谷氨酸受体影响谷氨酸,进而治疗抑郁症的作用机制,为探究中医药治疗抑郁症提供新的思路。

    Abstract:

    Glutamate is a major excitatory neurotransmitter in the central nervous system and a potential neurotoxin. During the development of depression, the glutamate concentration increases in the hippocampus. When glutamate accumulates, it causes serious damage to neurons and brain tissue, aggravating the depressive state. Therefore,glutamate accumulation may be a major mechanism of depression development. Astrocytes, glutamate transporters, and glutamate receptors play important regulatory roles in the glutamate concentration. This article reviews the mechanism-ofaction of traditional Chinese medicine on depression by regulating astrocytes, glutamate transporters, and glutamate receptors, and provides new ideas to explore treatment of depression by traditional Chinese medicine.

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李 超,李继安,高振安,申明宇,蒲菁菁,王 萌.中医药调控谷氨酸治疗抑郁症的研究进展[J].中国比较医学杂志,2024,34(3):133~141.

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  • 收稿日期:2023-06-20
  • 在线发布日期: 2024-05-29
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