College of Pharmacy, Harbin University of Commerce, Harbin 150076, China 在期刊界中查找 在百度中查找 在本站中查找
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College of Pharmacy, Harbin University of Commerce, Harbin 150076, China
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摘要:
卵巢功能不全(premature ovarian insufficiency,POI)又称“卵巢功能低下”,其发病率高达 1% ~ 5%,近年来还呈现不断上升的趋势,已经严重影响女性的身心健康及生活质量。 目前,关于 POI 的发病原因及机制尚不明确,模型构建方法与应用也较混乱,且绝大多数模型在针对性、稳定性等方面存在一定不足,这也极大的限制了 POI 的相关研究及其临床诊断和治疗。 因此本文对 POI 的病因病机与 POI 动物模型的构建进行综述和讨论,以期为 POI 的病因病机研究及模型的选择和构建提供更多参考。
Premature ovarian insufficiency (POI), also known as “ ovarian insufficiency”, has an incidence of 1% ~ 5%. The incidence has been on the rise in recent years, seriously affecting women’s physical and mental health and quality of life. At present, the cause and mechanisms of POI are still unclear, and the method and applications of model construction are also confusing. Most models have some shortcomings in pertinence and stability. The limitations greatly limit research into the clinical diagnosis and treatment of POI. This paper summarizes and discusses the etiology and pathogenesis of POI and the construction of POI animal models to provide a comprehensive reference for those studying POI.