1.河南中医药大学,郑州 450000;2.河南中医药大学第一附属医院,郑州 450000
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1. Henan University of Chinese Medicine, Zhengzhou 450000, China.2. the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000
脑卒中后认知障碍(post-stroke cognitive impairment,PSCI)是脑卒中后常见并发症之一,对卒中患者的生活质量影响较大,但发病机制尚未能完全解释清楚。 越来越多的证据表明,程序性细胞死亡( programmed cell death,PCD)机制与 PSCI 有关,包括细胞凋亡、坏死性凋亡、细胞焦亡、泛凋亡、PARP-1 依赖性细胞死亡和铁死亡等。 因此,清楚了解各种 PCD 机制及其与 PSCI 的关系,阐明 PCD 在疾病发病机制中的作用至关重要。 文章综述了与 PSCI 相关的 6 种 PCD 途径,总结其在 PSCI 中的作用机制,并阐述了不同途径之间可能存在的串扰,以期为临床靶向 PCD 途径的调节因子来治疗 PSCI 提供资料依据。
Post-stroke cognitive impairment ( PSCI) is a common complication after stroke, which significantly affects quality of life. However, the pathogenesis has not been fully explained. Increasing evidence has shown that the mechanism of programmed cell death (PCD) is related to PSCI, including apoptosis, necroptosis, pyroptosis, PANoptosis, parthanatos, and ferroptosis. Therefore, it is crucial to clearly understand the various mechanisms of PCD and their relationship with PSCI, and to elucidate the role of PCD in PSCI pathogenesis. The article reviews six PCD pathways related to PSCI, summarizes their mechanisms of action in PSCI, and elucidates the possible crosstalk among pathways to provide a basis for clinical targeting of regulatory factors in the PCD pathway for PSCI treatment.
孙可心,肖雨倩,万 俊,陈淑颖,陈丽敏,王 岩,白艳杰.程序性细胞死亡在脑卒中后认知障碍中的研究进展[J].中国比较医学杂志,2024,34(3):161~171.
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