Alzheimer’ s disease ( AD) is a neurodegenerative disorder characterized by widespread dementia.Despite the extensive research conducted on the pathogenesis of AD over the past 50 years, the underlying mechanisms responsible for AD-related cellular damage and cognitive impairment remain elusive. Multiple studies have confirmed alterations in the glucose metabolism patterns occur within the nerve cells of individuals with AD. This metabolic transition plays a crucial role in cell survival and disease progression, occurring decades before pathological changes and cognitive dysfunction even manifest. This article provides an overview of the potential mechanisms through which glucose metabolism reprogramming contributes to AD development in various types of nerve cells and brain regions, as well as the implication of their interplay. We aim to establish a foundation for further investigations into AD while offering insights and ideas for the development of novel preventive and therapeutic approaches.