调节性细胞死亡在扩张型心肌病中的研究进展
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作者单位:

1.河南中医药大学第二临床医学院,郑州 450053;2.河南省中医院,郑州 450053

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125

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R-33


Research progress on the relationship between regulatory cell death and dilated cardiomyopathy
Author:
Affiliation:

1. the Second Clinical School of Henan University of Chinese Medicine, Zhengzhou 450053, China.2. Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou 450053

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    摘要:

    扩张型心肌病( dilated cardiomyopathy,DCM)起病隐匿,以左心扩大甚至全心扩大为主要影像学表现,是心力衰竭与心律失常的常见原发疾病之一。 随着近年来研究的不断深入,调节性细胞死亡( regulatory cell death,RCD)的内在分子机制逐渐清晰,研究者们发现 RCD 方式在 DCM 的发生发展过程中扮演了十分重要的角色。 目前已知 DCM 中所涉及的 RCD 方式主要包括凋亡、坏死性凋亡、焦亡、铁死亡、自噬、铜死亡等,并且它们之间具有一定的相关性,可相互作用和调控。 本文就上述 6 种 RCD 方式参与 DCM 的机制研究现况进行概述,以期为未来基础研究及临床应用提供参考。

    Abstract:

    Dilated cardiomyopathy (DCM) has a concealed onset with left or even whole heart enlargement as the main imaging manifestation. It is a common primary disease of heart failure and arrhythmia. With the continuous deepening of research in recent years, the intrinsic molecular mechanism of regulatory cell death (RCD) has gradually become clear. Researchers have found that the RCD mode plays a very important role in the occurrence and development of DCM. At present, the RCD modes involved in DCM mainly include apoptosis, necrotic apoptosis, pyroptosis, iron death, autophagy, and cuproptosis, and a certain correlation exists among them, which interact and regulate each other. This article provides an overview of the current research status on the mechanisms of the six RCD modes involved in DCM to provide a reference for future basic research and clinical applications.

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邱月清,王振涛,陈振翼,常红波,禹笑阳,薛祎琨.调节性细胞死亡在扩张型心肌病中的研究进展[J].中国比较医学杂志,2024,34(5):~113.

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  • 收稿日期:2023-07-25
  • 在线发布日期: 2024-06-26
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